BAsic information description A chronic, inflammatory disease that mainly affects the joints. It often begins between ages 25 and 50, and is more common in women. frequent signs and symptoms Redness, pain, warmth, and tenderness in the affected joints. They may be in the hands and wrists (most often), elbows, shoulders, feet, and ankles. Morning stiffness. Muscle aches, weakness, fever, weight loss. Feeling generally unwell. Nodules (bumps) under the skin...